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. 2021 Mar 22;12:611739. doi: 10.3389/fmicb.2021.611739

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Copyright © 2021 Gao and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prediction model of direct electron uptake in Methanosarcina barkeri, cited (Holmes et al., 2018). The black arrows represent the possible transfers of electrons via F₄₂₀ and Fd. The red arrow represents the possible route for electron uptake from the outside. The unknown electron transfer proteins may gain 8 e^— from external sources and then channel these electrons via MP/MPH₂ to Fpo. Fpo can utilize F₄₂₀/F₄₂₀H₂ to deliver electrons to the process of CO₂ to CH₄.