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. 2021 Mar 22;12:581726. doi: 10.3389/fgene.2021.581726

Figure 1.

Figure 1

Genome Organization of SARS-CoV-2. (A) Complete virion structure: SARS-CoV-2 appears like a crown shape under the electron microscope. It is comprised with nucleocapsid (N), which wrapped the RNA genome, envelope (E), membrane (M), and spike (S) proteins. (B) RNA genome sequence (full-length RNA, 29,903 nucleotides (nt): SARS-CoV-2 composed with the total six open reading frames (ORFs) in which first two (ORF1a/b) occupy the two-third of the RNA genome. The later ORFs encode structural proteins, such as nucleocapsid (N), envelope (E), membrane (M), spike (S) and other accessory proteins (3a, 6, 7a, 7b, 8, and 10 [yet to validate its presence]). CTD, C-terminal domain; E, envelope; M, membrane; N, nucleocapsid; NTD, N-terminal domain; ORF1a/b, open reading frame; RBD, receptor-binding domain; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2; S, spike; TRS-B, transcription-regulatory sequence body; TRS-L, transcription-regulatory sequence leader.