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. 2021 Mar 22;15:589906. doi: 10.3389/fnins.2021.589906

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Copyright © 2021 Ferrari, Roda, Priori, De Luca, Facoetti, Ravera, Brandalise, Locatelli, Rossi and Bottone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TEM ultrastructural analysis. (A) U251 control cells: arrowhead indicates the mitochondria with a physiological feature; asterisk identifies a well-visible nucleolus with a decondensed chromatin. A well-organized endoplasmic reticulum (ER) is also visible in the perinuclear zone (thin arrows). (B–D) U251 cells after 10 μM (OC-6-44)-acetatodiamminedichlorido(2-(2-propynyl)octanoato)platinum(IV) [Pt(IV)Ac-POA] 48-h continuous treatment (CT). (B) Chromatin condensation (asterisk) and absence of the nuclear envelope (thin arrows) in apoptotic cells. (C) Several vacuoles engulfed with cell debris (arrowheads) in autophagic cells. (D) Typical necroptotic features accompanied by a partially preserved cytoplasmic membrane. Scale bar, 5 μm.