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. 2021 Mar 22;15:650971. doi: 10.3389/fnins.2021.650971

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Copyright © 2021 Bonaz, Sinniger and Pellissier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pilot study of vagus nerve stimulation (VNS) in patients with moderate to severe Crohn’s Disease (CD). Twelve-month-VNS effect on cytokinergic profile. A plasma cytokinergic profile for controls (red), before (black), 6-month (gray) and 12-month (pink) VNS has been assessed using PCA analysis of plasma multicytokines assay for all CD patients [IL1b, IL2, IL6, IL10, IL12(p70), IL17A, IL21, IL23, MIP1α, IFNγ, GM-CSF, TNFα, TGFβ1 and MCP1]. The control values are well grouped, while profiles before VNS are very scattered, indicating that CD patients have their own cytokinergic profile. After 6 months, and even more after 12 months of VNS, the points are tightened, indicating that cytokine levels evolve through a more “common” profile. Ellipses are centered on the barycenter (big dots) of each group. Adapted from Sinniger et al. (2020).