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. 2021 Mar 22;9:640957. doi: 10.3389/fcell.2021.640957

FIGURE 4.

FIGURE 4

Effect of topotecan and cabozantinib on the growth of NCI-H460 and NCI-H460/TPT10 tumors in male nude mice. (A,C) The images of resected tumors at the end of the treatment period from nude mice (n = 6 per treatment group) implanted with NCI-H460 and NCI-H460/TPT10 tumors. (B,D) The changes in NCI-H460 tumor volume and NCI-H460/TPT10 tumor volume throughout the study after the implantation. Data points and error bars represent the mean and SD of tumor volume (n = 6). and #signs were shown in the same color scheme as the figure legends. p < 0.05 versus the vehicle group; #p < 0.05 versus the topotecan only group.