Table 1.

Characteristics of experimental animal models for absence seizures

Most Important Feature	Pharmacologic Animal Models	Genetic Animal Models
EEG and behavior similar to the human condition	LD-PTZ, GHB, THIP, AY-9944, MAM-AY	GAERS, WAG/Rij, Lethargic, slow-wave-epilepsy mouse, tottering mouse
Reproducibility and predictability	LD-PTZ, GHB, THIP, AY-9944, MAM-AY	GAERS, WAG/Rij, lethargic
Quantifiable	LD-PTZ, GHB, THIP, AY-9944, MAM-AY	GAERS, WAG/Rij, lethargic
Appropriate pharmacology	LD-PTZ, GHB, PLC, AY9944	GAERS, WAG/Rij, Lethargic, slow-wave epilepsy, tottering
Unique developmental profile	LD-PTZ, GHB, AY9944	GAERS, WAG/Rij, lethargic
Exacerbated by GABAergic drugs	LD-PTZ, GHB, AY9944, MAM-AY	GAERS, WAG/Rij, lethargic
Involvement of thalamocortical mechanisms	LD-PTZ, GHB, PLC, AY9944, MAM-AY	GAERS, WAG/Rij, lethargic
Blocked by GABAB receptor antagonists	LD-PTZ, GHB, AY9944, MAM-AY	GAERS, WAG/Rij,