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. 2020 Autumn;19(4):160–168. doi: 10.22037/ijpr.2020.113321.14236

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Histological analysis of mice ovaries Control mice ovary showing normal follicles and corpus luteum; (B) PCOS mice ovary treated with estradiol valerate showing degeneration in follicles at development stages (atresia); (C) Photomicrograph of mice ovary treated with E.V plus CC showing more active ovary than PCOS with follicles as well as corpora lutei, preantral follicle and antral follicle; (D) Mice ovary treated with E.V plus metformin showing follicles in different developmental stages, as well as corpus luteum. SF: secondary follicle; PA: pre-antral follicle; AL: antral follicles; aF: atratic follicle: CL: corpus luteum. (H&E x20)