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. 2021 Mar 22;11:633899. doi: 10.3389/fonc.2021.633899

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Copyright © 2021 Du, Zhang, Yin, Wang, Yan, Xie, Zheng, Zheng, Li and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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WGCNA of DEGs in CCA samples. (A) Examination of the scale-free fit index for distinct soft-thresholding powers (β). (B) Examination of the mean connectivity for distinct soft-thresholding powers. (C) Clustering dendrogram of filtered DEGs due to a dissimilarity measure. (D) Heatmap showing the connection between module eigengenes and five clinical traits of CCA. (E) Distribution of mean gene significance and errors in the modules correlated with tumor grade of CCA. WGCNA, weighted gene co-expression network analysis.