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. 2021 Mar 22;11:659048. doi: 10.3389/fonc.2021.659048

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Copyright © 2021 Šteňo, Buvala, Babková, Kiss, Toma and Lysak

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Right-sided temporal glioblastoma (Left column) preoperative navigation 3D contrast-enhanced T1-weighted MRI sequence displaying high-grade tumor showing typical ring enhancement (Right column) pre-resectional 3D IOUS image fused with navigation MRI. Note that the hyperechoic high-grade tumor tissue is not selectively identifiable on the IOUS image, as the surrounding edematous and infiltrated brain (non-enhancing on MRI) is hyperechoic as well. 3D, three-dimensional; MRI, magnetic resonance imaging; IOUS, intraoperative ultrasound.