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. 2021 Mar 22;12:653189. doi: 10.3389/fimmu.2021.653189

Table 1.

Binding capacity analysis of the top 20 NAbs.

Number Antibody Viral protein binding
EC50-S1 (µg/ml) EC50-S-RBD (µg/ml) Association (Kka,1/Ms) Dissociation (Kkd,1/s) Affnity (KD, nM)
1 58G6 0.032 0.034 8.64×105 3.32×10-4 0.39
2 510A5 0.049 0.057 2.78×105 2.17×10-3 7.80
3 13G9 0.026 0.035 7.25×105 4.87×10-3 6.70
4 510A4 0.039 0.050 1.64×106 1.24×10-3 0.75
5 51D3 0.054 0.058 5.56×104 1.17×10-4 2.11
6 55A8 0.031 0.035 3.44×105 2.75×10-4 0.80
7 51A1 0.026 0.024 6.52×104 6.36×10-5 0.98
8 81E1 0.043 0.038 1.07×106 6.99×10-4 0.65
9 51E10 0.070 0.101 4.53×105 1.05×10-3 2.30
10 51D7 0.037 0.044 4.74×105 1.15×10-3 2.40
11 07C1 0.095 0.106 9.66×104 5.56×10-5 0.58
12 53H3 0.022 0.037 7.92×104 1.58×10-4 2.00
13 52F7 0.025 0.029 5.11×105 2.90×10-4 0.57
14 57B8 0.013 0.023 1.15×105 3.45×10-5 0.30
15 57F7 0.079 0.124 4.63×105 3.80×10-5 0.08
16 51D4 0.088 0.131 7.22×104 1.46×10-4 2.02
17 55C9 0.029 0.061 7.91×104 8.76×10-5 1.10
18 56D7 0.027 0.051 2.71×105 2.44×10-4 0.90
19 510H2 0.060 0.086 5.56×104 4.46×10-4 8.00
20 81C3 0.046 0.057 2.43×105 5.82×10-3 24.00