Table 1.

Autoreactive T cell targets in multiple sclerosis: evidence for relevance.

Protein	Peptide	Recognized by brain- and/or CSF-infiltrating T cells	Tolerizing activity in humans	Immuno-dominant in MS patients	High avidity recognition	Encephalitogenic (EAE)	Encephalitogenic in humanized models	References(see supplement for detailed list)
MBP	Protein							S1,S2
	Ac 1-9							S3-S7
	13-31							S3-S8
	30-44 (p.i.)							S9, S10
	69-86							S4
	79-87							S4, S11, S12
	83-99* (p.i.)							S9, S13-S19
	96-109							S4
	110-118							S20
	111-129							S8, S21, S22
	130-144 (p.i.)							S9, S10
	140-154 (p.i.)							S9, S10
	146-170							S9, S23
PLP	Protein							S24, S25
	40-60						*	S26-S29
	56-70							S27, S30
	89-106							S31-S34
	95-117							S31
	139-154							S35, S36
	178-197							S26, S37
	190-208							S25
	184-209							S25, S37
	217-233							S38
MOG**	Protein							S39-S45
	1-20							S46-S48
	11-30							S47
	21-40							S20, S49
	31-50							S20, S49
	35-55							S8, S46, S49-S51
	63-87							S47, S48
	64-96							S46, S49, S52-S56
	97-108							S52-S56
	119-132							S58, S59
	146-154							S56, S58
	181-195							S58, S59
	186-200							S58, S59
MOBP	15-36							S60-S62
	21-39					***		S60, S63
	37-60							S63
	65-86/55-77							S61, S64
CNPase	Protein							S60, S65
	343-373							S66
	356-388							S66-68
MAG								S65, S69-S75
OSP/claudin 11								S65, S76-S81
TSTA3****	51-65							S82 Own unpublished data
	136-150							S82 Own unpublished data
	242-251							S82 Own unpublished data
	296-310							S82 Own unpublished data
RASGRP2****	78-87							S83 Own unpublished data
Transaldolase H								S84-S87
α-B Crystallin								S88-S95
Neurofascin *****								S96-S98
Contactin-2/TAG-1								S98-S100

green color indicates that the respective evidence has been shown, red color that it has been tested and was negative. White = not known and/or not done. For some peptides, independence of antigen processing has been documented. If this was the case, it is indicated after the amino acid number by “(p.i.)”. The table only mentions T cell antigens. Antibody targets, e.g. KIR4-1 or anoctamin-2, have been omitted. MBP, myelin basic protein; PLP, proteolipid protein; MOG, myelin oligodendrocyte glycoprotein; MOBP, myelin associated oligodendrocyte basic protein; CNPase, 2’,3’-Cyclic-nucleotide 3’-phosphodiesterase; MAG, myelin-associated glycoprotein; OSP, oligodendrocyte-specific protein; RASGRP2, Ras-guanyl releasing protein 2; TSTA3, GDP L-fucose synthase.

*Humanized TCR and A*03:01 transgenic mouse.

**Exclusive expression in the CNS debated (Pagany et al. Neurosci. Lett. 2003).

***Encephalitogenic epitope in EAE different.

****Immunodominant epitopes in part mapped, but studies ongoing.

*****Anti-neurofascin antibodies lead to axonal damage when combined with co-transfer of myelin-specific T cells.

Extensive additional information on the topic can be found reviews from group (S2, S20).