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. 2021 Mar 22;11:609334. doi: 10.3389/fonc.2021.609334

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Copyright © 2021 Wang, Yan, Wang, Lin and Bi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical phenotype correlation. (A) Significant association between M2 macrophage frequency and co-expression genes are indicated. The correlation of CD163 was the highest at 0.57. (B) Combining infiltrating M2 macrophages elevated the predictive accuracy of risk score even more than either of them alone. The hazard of high ‘M2 + Risk score’ group showed more survival risk than the lower group (Kaplan–Meier analysis, M2 + risk score binary: HR = 2.316). (C) Clinical stage correlation to different expression level of CD163, CD209, CSF1, and MMD.