Baic, Piog, and Tan IIA are capable of undergoing NP packaging. TEM images of drug loaded PLGA NPs (A). The average NP sizes were 60.8, 74.2, and 52.2 nm for Baic-NPs, Piog-NPs, and Tan IIA-NPs, respectively. Hydrodynamic sizes of NPs were 89.28 ± 1.8, 122.4 ± 2.3, and 91.34 ± 1.3 nm for Baic-NPs, Piog-NPs, and Tan IIA-NPs, respectively (B). NPs zeta potentials were −31.91, −27.39, and −28.98 mV for Baic-NPs, Piog-NPs, and Tan IIA-NPs, respectively (C). Drug release profiles for Baic-NPs, Piog-NPs, and Tan IIA-NPs (D).