Table 3. Univariable and multivariable analysis of overall survival.

Variables		Univariable		Multivariable
		HR (95% CI)	P-value	HR (95% CI)	P-value
Regimen			0.006		0.152
	FOLFOX	Ref.		Ref.
	XELOX	0.972 (0.616–1.535)	0.904	0.644 (0.413–1.005)	0.052
	SOX	0.507 (0.329–0.779)	0.002	0.853 (0.531–1.372)	0.513
Preoperative cycles			0.068		0.534
	≥4	Ref.		Ref.
	3–4	0.569 (0.337–0.962)	0.035	0.844 (0.483–1.472)	0.550
	1–2	0.540 (0.313–0.931)	0.027	0.731 (0.413–1.294)	0.282
Concomitant resection
	No	Ref.		Ref.
	Yes	1.616 (1.002–2.606)	0.049	0.720 (0.443–1.334)	0.184
ypT			<0.001		0.005
	ypT4	Ref.		Ref.
	ypT0	0.161 (0.051–0.508)	0.002	0.278 (0.087–0.883)	0.030
	ypT1	0 (0–1.79×10174)	<0.001	0 (0–1.49×10207)	<0.001
	ypT2/3	0.279 (0.141–0.550)	<0.001	0.357 (0.180–0.708)	0.003
ypNr stage			<0.001		<0.001
	ypNr0	Ref.		Ref.
	ypNr1	4.794 (1.878–12.238)	0.001	3.507 (1.371–8.967)	0.009
	ypNr2	12.641 (5.037–31.720)	<0.001	7.535 (2.988–19.004)	<0.001
	ypNr3	22.643 (8.860–57.865)	<0.001	13.735 (5.344–35.304)	<0.001
Histological grade			<0.001		0.433
	Well-differentiated	Ref.		Ref.
	Poor-differentiated	2.007 (1.129–3.566)	0.018	1.553 (0.650–3.709)	0.322
	Gx	0.320 (0.091–1.125)	0.076	0.566 (0.104–3.093)	0.511

HR = hazard ratio; CI = confidence interval; SOX = S-1 combined with oxaliplatin; FOLFOX = fluorouracil, leucovorin, and oxaliplatin; XELOX = capecitabine combined with oxaliplatin.