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. 2020 Oct 20;31(4):594–604. doi: 10.1136/ijgc-2020-001822

Figure 2.

Figure 2

Study design of the PORTEC-4a trial. Reproduced with permissionfrom 'Molecular-integrated risk profile to determine adjuvant radiotherapy in endometrial cancer: evaluation of the pilot phase of the PORTEC-4a trial' by Wortman et al.58 CTNNB1, β-catenin; EBRT, external beam radiation therapy; HIR, high-intermediate risk; LVSI; lymphovascular space invasion; MMRd, mismatch repair deficiency.* High-intermediate risk endometrial cancer: stage IA (with invasion) and grade 3; stage IB, grade 1 or 2 with either age ≥60 or substantial lymphovascular space invasion; stage IB, grade 3 without lymphovascular space invasion; or stage II (microscopic) and grade 1.