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. 2021 Apr 5;127(1):e32–e34. doi: 10.1016/j.bja.2021.03.026

Fig 1.

Fig 1

Cellular SARS-CoV-2 binding sites. ACE2, angiotensin converting enzyme 2; BiP, heavy chain binding immunoglobulin protein, also known as glucose regulating protein 78 (GRP78) or heat shock 70 kDa protein 5 (HSPA5) in the endoplasmic reticulum (ER); Sig-1R, sigma-1 receptor; ↑, upregulation; ⇑, activation; ⇓, inhibition.