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. 2021 Apr 5;2(5):100247. doi: 10.1016/j.patter.2021.100247

Figure 3.

Figure 3

Network of consensus DEGs of SARS-CoV-2 infection models and SARS-CoV-2-host protein-protein interactions

(A) Network of 176 DEGs of three SARS-CoV-2 infection models that encode proteins interacting with SARS-CoV-2 viral proteins. The orange- and purple-colored nodes are consensus up- or downregulated genes, respectively, while the three genes with black border (PTBP2, CEP350, and CYB5B) are part of the core set of genes.

(B) STRING-based interaction network of consensus DEGs and SARS-CoV-2-human viral-host protein interactome.

(C–I) Example gene clusters from the consensus DEG and SARS-CoV-2-host integrated interactome. Clusters (based on MCL network clustering) shown are C-5 (C), C-9 (D), C-11 (E), C-13 (F), C-7 (G), and C-8 (H). Consensus up- and downregulated genes are in orange and purple, respectively, while the hexagonal genes are part of the SARS-CoV-2-host protein interactome, directly interacting with the consensus DEGs.