. 2021 Mar 30;26(1):32–40. doi: 10.15430/JCP.2021.26.1.32

Table 2.

List of significantly changed metabolites in the bile acid pathway

Metabolites	Biochemical pathways	Metabolites	Fold control

			A/WT		AF/WT
Mucosa	Primary bile acid metabolism	Cholate sulfate	0.05^b		0.25^b
Plasma	Secondary bile acid metabolism	Deoxycholate	3.19^a		2.03^a

			A/WT	AF/WT		AF/A

Mucosa	Primary bile acid metabolism	Cholate	1.33	4.49^a		3.38^a
		Chenodeoxycholate	1.13	4.95^a		4.37^a
		Beta-muricholate	0.86	2.68^a		3.11^a
	Secondary bile acid metabolism	Deoxycholate	3.02^a	7.65^a		2.53^a
		Taurodeoxycholate	2.75	6.29^a		2.28^a
		6-beta-hydroxylithocholate	2.1^a	4.29^a		2.05^a
		7-ketolithocholate	5.92^a	11.94^a		2.02^a
		Hyocholate	0.84	3.55^a		4.23^a
		3-dehydrocholate	1.11	3.1^a		2.8^a
		7-ketodeoxycholate	0.9	3.83^a		4.24^a

Fold change is calculated as the ratio of the Apc^Min/+ (A) vs. WT, Apc^Min/+-Ffar2^-/- (AF) vs. WT, and Apc^Min/+-Ffar2^-/- vs. Apc^Min/+. Fold change that is labeled ^a or ^b presents significantly increased or significantly decreased, respectively. WT, wild-type. P < 0.05.