Table 2.
Results of the 353 women with hr-HPV mRNA positive self-samples attending the follow-up examination including status of hr-HPV at cervix, cytology- and histological assessments
| Cytology | Hr-HPV status cervix | Histology |
|---|---|---|
| No cytologia (n = 10) | Positive: 0 (0) | - |
| Negative: 10 (100) | No histology: 9 Benign: 1 |
|
| Benign (n = 225) | Positive: 52 (23.1) | No histology: 51 Benign: 1 |
| Negative: 173 (76.9) | No histology: 173 | |
| ASCUS (n = 46) | Positive: 35 (76.1) | No histology: 15 Benign: 14 LSIL: 5 HSIL: 1 |
| Negative: 11 (23.9) | No histology: 7 Benign: 4 |
|
| LSIL (n = 39) | Positive: 38 (97.4) | No histology: 17 Benign: 12 LSIL: 7 HSIL: 2 |
| Negative: 1 (2.6) | No histology: 1 | |
| ASC-H (n = 7) | Positive: 7c (100) | Benign: 1 LSIL: 1 HSIL: 5 |
| Negative: 0 (0) | - | |
| HSIL (n = 26) | Positive: 26c (100) | No histology: 1 Benign: 1 HSIL: 21 Cancer: 3b |
| Negative: 0 (0) | - | |
| Total (n = 353) | Total positive: 158 (44.8) Total negative: 195 (55.2) |
Total no histology: 274 Total benign: 34 Total LSIL: 13 Total HSIL: 29d Total cancer: 3d |
Values are presented as number only or number (%). Hr-HPV, high-risk human papillomavirus; HPV, human papillomavirus; ASCUS, atypical squamous cells of undetermined significance; LSIL, low grade squamous intraepithelial lesion; ASC-H, atypical squamous cells cannot exclude HSIL; HSIL, high grade squamous intraepithelial lesion. aThe reason for no cytological diagnosis was due to insufficient material in six of the test samples and no cytology taken for four samples. bTwo cases of cervical cancer, one case of vaginal cancer. cFor calculation of positive predictive value (PPV) for self-samples the frequency of ASC-H and HSIL (n = 33) was used as the numerator and the sum of HPV-positive self-samples (n = 353) was denominator: 9.3% ([33/353], 95% CI = 6.5-12.9) for detection of cytological severe dysplasia. The HPV mRNA test performed on cervical samples at follow-up showed a PPV of 20.9% ([33/158], 95% CI = 14.8-28.1) for detection of cytological severe dysplasia. dThe histologically confirmed prevalence of HSIL or cancer was 9.1% ([32/353], 95% CI = 6.3-12.6) among women attending the follow-up.