Table 6. Use of miltefosine for Balamuthia GAE.

AmB: amphotericin B, Rif: rifampin, Flu: fluconazole, AZM: azithromycin, Dex: dexamethasone, Acy: acyclovir, Van: vancomycin, CFX: ceftriaxone, Deoxy AmB IV: deoxycholate amphotericin B intravenously, TMP-SMX: trimethoprim-sulfamethoxazole, 5-FC: flucytosine, GAE: granulomatous amebic encephalitis

Reference	Case (age, sex)	Diagnosis from symptom to onset	Initial treatment	Miltefosine initiation from diagnosis	Total days of treatment	Outcome	Follow-up
[33]	21, female	Four months	Fluconazole, clotrimazole, topical steroid, fluconazole and clarithromycin, TMP-SMX, albendazole	> two years	one year	Survived	30 months of treatment including 12 months without therapy or recurrence
[34]	26, male	Two months	Dex, albendazole, Azm, Flu,TMP-SMX	Third week	114 days	Survived	Continued nine months of treatment minus miltefosine
[35]	69, female	Three days	Azm, Flu, 5-FC, Sulfadiazine, pentamidine	On 3rd day	Three days	Died	A few weeks after transfer to hospice care
[36]	11, male	Weeks	Dex, AmB, Flu, Azithromycin, 5-FC, Sulfadiazine, pentamidine, metronidazole	On 7th day	27 days	Died	Palliative care on day 49