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. 2021 Mar 19;45(5):68. doi: 10.3892/or.2021.8019

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Enzymatic pathways of endogenous H₂S production in mammalian systems. CBS and CSE may produce H₂S in the cytosol whereas 3MST mainly generates H₂S in mitochondria. These pathways utilize l-cysteine as a main precursor of H2S. H₂S, hydrogen sulfide; CBS, cystathionine β-synthase; CSE, cystathionine γ-lyase; 3MST, 3-mercaptopyruvate sulfurtransferase; CAT, cysteine aminotransferase; 3MP, 3-mercaptopyruvate.