Figure 2.

LPS Exposure Induces an Acute Sickness Response, From Which Animals Recovered. Health screen scores for animals exposed to saline were grouped together as they did not significantly differ across time. There was a significant effect of LPS exposure on sickness behavior when compared to saline injected animals (F10,157 = 12.69, p < 0.0001). Dunnett’s post-hoc analysis indicated that when compared to saline-treated animals, animals exposed to LPS exhibited significant sickness behavior four hours post-injections 1, 2, and 4, while injection 5 trended towards significance (p = 0.0667). Further, health sickness scores at the 13 day time point did not significantly differ from those in the saline-injected group, indicating that animals returned to normal health status. Data are expressed as mean ± SEM; one-way ANOVA. **p < 0.01 and ****p < 0.0001.