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. 2021 Feb 24;13:1759091421991769. doi: 10.1177/1759091421991769

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Autophagy-Related Genes Are Downregulated in the Ipsilateral Hemisphere of LPS Exposed Stroke Animals. A: In the contralateral hemisphere, only saline injected animals had a significant reduction in Beclin-1 mRNA expression when compared to sham controls (F2, 26 = 4.644, p = 0.0189). B: Both saline and LPS injected animals expressed significantly lower levels of Beclin-1 in the ipsilateral hemisphere when compared to sham controls (F2, 31 = 5.457, p < 0.0093). In the contralateral hemisphere, no significant differences in (C) ATG5, (E) LC3a, or (G) LC3b mRNA expression were observed. In the ipsilateral hemisphere, significant downregulation of (D) ATG5 (F2, 31 = 3.972, p = 0.0291), (F) LC3a (F2, 31 = 3.393, p = 0.0465), and (H) LC3b mRNA expression was observed in the LPS exposed stroke animals when compared to sham controls. Data are expressed as mean ± SEM; one-way ANOVA with Dunnett’s post hoc test; brackets connect statistically significant groups; *p < 0.05.