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. 2021 Mar 31;49(3):03000605211002379. doi: 10.1177/03000605211002379

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© The Author(s) 2021

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — The characterization of plasma exosomes and several exosomal microRNAs (miRNAs) in patients with idiopathic pulmonary arterial hypertension (IPAH) in the study group (n = 12). (a) Images of plasma exosomes under transmission electron microscopy. (b) The levels of two exosome markers, tumour susceptibility gene 101 protein (TSG101) and CD63, in exosomes as determined by Western blot analysis. (c) Particle size distribution of exosomes. (D–G) The levels of several plasma exosomal miRNAs in patients with IPAH stratified according to survival during follow-up. Data presented as dot plots with the mean shown as the central black horizontal line and the error bars indicating the SD; independent-sample t-test.