Table 1.
Baseline demographic and haemodynamic characteristics of patients with idiopathic pulmonary arterial hypertension (IPAH) that were enrolled in a study to investigate if plasma exosomal miRNA levels can predict prognosis.
| Characteristic | Study group n = 12 | Validation group n = 46 |
|---|---|---|
| Baseline characteristics | ||
| Age, years | 36.3 ± 1.8 | 44.6 ± 15.6 |
| Sex, male/female | 5/7 | 18/28 |
| Nonsurvivors | 4 | 15 |
| Heart rate, beats/min | 83.5 ± 17.3 | 80.6 ± 13.1 |
| SBP, mmHg | 113.0 ± 20.2 | 115.5 ± 19.9 |
| DBP, mmHg | 71.7 ± 11.8 | 70.9 ± 13.8 |
| BSA, m2 | 1.6 ± 0.1 | 1.6 ± 0.2 |
| 6MWD, m | 378.9 ± 84.8 | 362.8 ± 92.5 |
| WHO-FC, n (%) | ||
| I–II | 4 (33.3) | 17 (37.0) |
| III–IV | 8 (66.7) | 29 (63.0) |
| Haemodynamic characteristics | ||
| mRAP, mm Hg | 6.4 ± 5.4 | 5.9 ± 4.5 |
| mPAP, mm Hg | 69.7 ± 22.0 | 63.0 ± 10.6 |
| mPAWP, mm Hg | 9.6 ± 2.5 | 7.2 ± 3.4 |
| PVR, Wood units | 17.0 ± 4.6 | 15.3 ± 4.2 |
| CO, l/min | 4.2 ± 1.5 | 4.4 ± 1.2 |
| CI, l/min/m2 | 2.6 ± 1.0 | 2.8 ± 0.7 |
| Specific medications | ||
| PDE-5 inhibitors | 4 (33.3) | 18 (39.1) |
| ERA | 3 (25.0) | 10 (21.7) |
| Prostacyclin analogues | 2 (16.7) | 5 (10.9) |
| Combination | 2 (16.7) | 11 (23.9) |
| Nonspecific medication | 1 (8.3) | 2 (4.3) |
Data presented as mean ± SD or n of patients (%).
SBP, systolic blood pressure; DBP, diastolic blood pressure; BSA, body surface area; 6MWD, 6-minute walk distance; WHO-FC, World Health Organization Functional Class; mRAP, mean right atrial pressure; mPAP, mean pulmonary arterial pressure; mPAWP, mean pulmonary capillary wedge pressure; PVR, pulmonary vascular resistance; CO, cardiac output; CI, cardiac index; PDE-5, phosphodiesterase type 5; ERA, endothelin receptor antagonist.