Fig. 4.

PPD or OA administration enhances neurogenesis in the hippocampus of APP/PS1 mice. (A) Representative NeuN (green) and BrdU (red) staining in the dentate gyrus of brain sections from WT mice, APP/PS1 mice, and APP/PS1 mice treated with PPD or OA. Scale bars: 100 μm in the left panels, 40 μm in the right panels. (B) Quantification of BrdU⁺/NeuN⁺ cells in A. n = 5–6 mice per group. Error bars represent the mean ± SD. ∗∗p < 0.01, compared with the WT group; ^##p < 0.01, compared with the APP/PS1 group. PPD, 20(S)-protopanaxadiol; OA, oleanolic acid; BrdU, 5-bromo-2′-deoxyuridine; WT, wild type; SD, standard deviation.