Fig. 1.

Administration of G-Rb1 ameliorated MIA-induced arthritis in ovariectomized rats. (A) Body weight of the rats was measured once per week until the end of the experiment. (B) MIA-induced rats were given G-Rb1 at 3 or 10 μg/kg bw and their paw withdrawal threshold was measured using the von Frey filament test. (C) G-Rb1 administration in OA rats helped regain spleen weight. Diclofenac administration enhanced spleen weight compared to the normal control. (D) H&E staining of spleen sections of various groups indicates normal morphology. Significant differences between each group and the OA group are marked *p < 0.05. G-Rb1, ginsenoside Rb1; OA, osteoarthritis; MIA, monoiodoacetate; H&E, hematoxylin and eosin stain.