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. 2021 Mar 19;8:619759. doi: 10.3389/fvets.2021.619759

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Copyright © 2021 Park, Kim, Shim and Yoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ingenuity pathway analysis of the dendritic cell maturation signaling pathway in the DH82 cell line treated with Brucella canis. (A) Dendritic cell maturation pathway in a 24 h on coculture model (B) Fc gamma receptor- (FcγR-) associated pathway on dendritic cell maturation pathway, (B) is enlarged from a rectangle of (A). Genes with upregulation are shown in red, and genes with downregulation are shown in green. Orange indicates predicted activated genes, blue indicates predicted inhibited genes, and an uncolored node indicates that the genes were not differentially expressed in this pathway. The IPAs were produced using QIAGEN's IPA (https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). The increase in expression over time in this canonical pathway, especially in the FcγR-associated pathways, was evident in the coculture model.