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. 2021 Mar 19;8:619759. doi: 10.3389/fvets.2021.619759

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Copyright © 2021 Park, Kim, Shim and Yoo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ingenuity pathway analysis of the Toll-like receptor (TLR) signaling pathway in the DH82 cell line treated with B. canis. (A) TLR signaling pathway in 24 h on coculture model, (B) TRAF6-associated pathway on TLR signaling pathway, (B) is enlarged from a rectangle of (A) genes with upregulation are shown in red, and genes with downregulation are shown in green. Orange indicates the predicted activated genes, blue indicates the predicted inhibited genes, and an uncolored node indicates that the genes were not differentially expressed in this pathway. The IPAs were produced using QIAGEN's IPA (https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). A distinct change in gene expression was observed in the TRAP6-related pathway, and the coculture model confirmed that the expression of the related genes was increasing gradually.