Table 2.

Differentially expressed genes (DEGs) identified for each model and each time.

Gene symbol	Fold changes in coculture model			Fold changes in single-culture model
	2 h	12 h	24 h	2 h	12 h	24 h
FHIT	89.264	83.286	86.223	–	–	–
ACOD1	64.445	18.126	53.446	156.498	71.012	–
CXCL10	55.330	26.723	–	168.897	95.010	–
CCL4	45.887	13.642	410.148	149.086	184.823	302.334
OLR1	33.128	28.840	270.597	49.522	36.504	57.282
FFAR2	29.243	9.646	88.035	99.044	–	–
CCL5	22.943	18.636	63.119	63.558	81.572	85.627
SAA1	22.471	28.051	198.088	95.010	436.549	826.001
CCL3L3	20.393	22.316	719.076	60.969	286.026	588.134
IL1A	19.427	13.454	704.277	84.449	337.794	608.874
SAA1	17.388	21.407	116.970	74.028	328.557	481.036
NEURL3	16.679	13.086	54.569	27.284	–	–
IL1B	16.679	13.929	1002.926	77.708	1351.176	1144.102
SAA1	16.223	24.251	116.970	86.223	354.588	398.932
IL6	14.026	12.126	202.251	54.569	421.679	471.136
CXCL8	12.295	–	89.884	34.060	138.141	181.019
GPR84	12.042	10.556	88.035	19.562	52.346	–
FST	10.056	–	–	25.634	43.111	–
CXCL5	8.456	10.483	97.681	16.450	174.853	138.141
TNFAIP2	7.516	–	–	19.293	–	–
STEAP4	7.062	–	–	23.425	–	–
RASSF6	6.409	–	–	18.126	45.887	–
PTGS2	6.320	–	272.479	21.857	95.670	396.177
IL1RN	5.242	–	58.081	17.030	–	–
EGLN3	–	25.813	110.661	−3.182	–	108.383
TSHZ2	–	7.621	56.493	–	–	–
IL23A	–	–	1009.902	29.041	76.639	1418.352
SRGN	–	–	91.139	–	–	56.103
OSM	–	–	88.035	–	–	237.207
F3	–	–	48.840	–	–	75.061
LIF	–	–	48.503	–	38.586	–
INHBA	–	–	–	–	134.364	240.518
MMP3	–	–	–	–	54.569	247.280
MMP13	–	–	–	–	44.324	83.865
MMP10	–	–	–	–	38.854	168.897
FCRL2	–	–	–	–	36.252	64.000
SMPDL3A	–	–	–	–	33.359	53.446
SERPINB2	–	–	–	–	31.341	59.714

The main DEGs in which upregulation occurred in each experiment.