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. 2021 Mar 3;24:310–324. doi: 10.1016/j.omtn.2021.02.034

Table 2.

Univariate and multivariate Cox regression analyses of overall survival and disease-free survival in breast cancer patients

Covariate
Univariate analysis
Multivariate analysis
HR 95% CI p value HR 95% CI p value
Overall survival

Age (≤60 versus >60) 1.826 1.122–2.971 0.015∗ 2.097 1.209–3.637 0.008∗∗
Tumor stage (I + II versus III + IV) 2.777 1.697–4.545 0.000∗∗ 3.587 1.713–7.512 0.001∗∗
Tumor size (≤2 cm versus >2 cm) 2.327 1.217–4.448 0.011∗ 1.478 0.733–2.980 0.275
Lymph node metastasis (N0 versus N1–3) 2.132 1.284–3.537 0.003∗∗ 1.280 0.615–2.661 0.509
Race (Other/White) 0.639 0.361–1.130 0.124 0.577 0.319–1.045 0.070
Radiation (No/Yes) 0.572 0.343–0.953 0.032∗ 0.366 0.203–0.660 0.001∗∗
PCAT-1 gene alteration (low versus amplification) 2.364 1.458–3.833 0.000∗∗ 1.948 1.135–3.341 0.015∗

Disease-free survival

Age (≤60 versus >60) 0.817 0.478–1.396 0.459 0.912 0.516–1.615 0.753
Tumor stage (I + II versus III + IV) 3.109 1.870–5.166 0.000∗∗ 3.576 1.731–7.386 0.001∗∗
Tumor size (≤2 cm versus >2 cm) 2.089 1.086–4.017 0.027∗ 1.331 0.669–2.644 0.415
Lymph node metastasis (N0 versus N1–3) 1.707 1.021–2.854 0.042∗ 0.965 0.464–2.006 0.924
Race (Other/White) 0.525 0.297–0.927 0.026∗ 0.553 0.311–0.981 0.043∗
Radiation (No/Yes) 0.923 0.553–1.538 0.757 0.599 0.338–1.061 0.079
PCAT-1 gene alteration (low versus amplification) 2.049 1.238–3.392 0.005∗∗ 1.829 1.078–3.103 0.025∗

HR, hazard ratio; 95% CI, 95% confidence interval. ∗p < 0.05 and ∗∗p < 0.01.