Fig. 4.

Photomicrograph of skin (H & E; 100x).

Representative image of each group

(A) Control mice skin section showing normal arrangement of epidermis, dermis, hair follicles and sebaceous glands; (B) SM-4LD₅₀ arrow showing inflammation, atrophy dermoepidermal sepration; (C) NAC-50 showing hyalinization; (D) DRDE07−25; (E) DRDE07−50 (F) NAC-25+DRDE07−25 arrow showing coagulative necrosis of epidermis penetrating deep into dermis along with necrotic inflammatory cells; (G) NAC-50+DRDE07−50 showing mild to moderate decrease in severity of skin lesions compared to B; (H) NAC-100+DRDE07−50.