Table 3.
Lesions in liver, spleen and kidney tissues.
| Lesions | ABCDEFGH |
|---|---|
| Liver | |
| Necrosis/apoptosis | -+++++++++++++++ |
| Inflammatory foci | -++++++++++++ |
| Hepatocyte vacuolation | -+++++++++++++ |
| Kupffer cell hyperplasia | -+++++++++++++++ |
| Hepatocellular degeneration | -+++++++++++++++ |
| Granulovacuolar degeneration | -++++++++++++++ |
| Spleen | |
| Lymphoid depletion | -++++++++++++++ |
| Necrosis/ apoptosis | -++++++++++++++ |
| Exudation of fibrinous exudates | -+++++++++++++- |
| Depletion of germinal centre | -++++++++++++ |
| Skin | |
| Inflammation | -++++++++++++++++++ |
| Epidermal necrosis | -++++++++++++++++++ |
| Vacuolization of keratinocytes | -++++++++++++++ |
| Edema | -++++++++++++ |
| Hyperplasia of basal cells | -++++++++++++ |
| Dermoepidermal separation | -++++++++++++++++++++ |
| Adnexal atrophy | -++++++++++++++++++++ |
A = Control; B = SM-4LD50; C = NAC-50; D = DRDE07−25; E = DRDE07−50.
F = NAC-25+DRDE07−25; G = NAC-50+DRDE07−50; H = NAC-100+DRDE07−50.
Average of 6 observations in each group.
- nil; + minimal (< 12 %); ++mild (< 22 %); +++moderate (< 45 %); ++++ severe (> 45 %).