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. Author manuscript; available in PMC: 2021 Apr 5.
Published in final edited form as: Headache. 2009 Oct 21;50(3):459–478. doi: 10.1111/j.1526-4610.2009.01551.x

Fig 2.—

Fig 2.—

This schema represents the principal differences in [Na+]e and [K+]e predicted to occur at neurons for migraineurs in the Well State, during Aura, or during Migraine, based on the capillary endothelial cell Na+, K+ -ATPase transporter (CEC NKAT) theory. The boxed regions above each axon illustrate the effects from the Na+ changes on neuronal excitability: Normal action potentials in the Well State; cortical spreading depression (CSD) in Aura; increased action potential firing frequency in Migraine.