Table 1.
Cross-sectional analyses on the relation of cardiovascular disease and diabetes with radiographic and symptomatic knee OA.
| Baseline ROA in MOST | Baseline SxOA in MOST | |||||
|---|---|---|---|---|---|---|
| N (knees) | Events | OR* (95% CI) | N (knees) | Events | OR* (95% CI) | |
| CVD | ||||||
| No | 5283 | 2118 | 1.0 (reference) | 5281 | 923 | 1.0 (reference) |
| Yes | 737 | 357 | 1.00 (0.81–1.24) | 734 | 170 | 1.15 (0.90–1.47) |
| Diabetes | ||||||
| No | 5428 | 2166 | 1.0 (reference) | 5424 | 921 | 1.0 (reference) |
| Yes | 558 | 288 | 0.80 (0.63–1.03) | 557 | 159 | 1.09 (0.84–1.41) |
| Baseline ROA in OAI | Baseline SxOA in OAI | |||||
| N (knees) | Events | OR* (95% CI) | N (knees) | Events | OR* (95% CI) | |
| CVD | ||||||
| No | 8058 | 3518 | 1.0 (reference) | 8051 | 1655 | 1.0 (reference) |
| Yes | 526 | 270 | 0.94 (0.75–1.17) | 526 | 141 | 1.17 (0.91–1.51) |
| Diabetes | ||||||
| No | 7997 | 3462 | 1.0 (reference) | 7990 | 1614 | 1.0 (reference) |
| Yes | 648 | 348 | 0.86 (0.69–1.06) | 648 | 183 | 0.95 (0.75–1.20) |
ROA, Radiographic OA; MOST, Multicenter Osteoarthritis Study; SxOA, symptomatic OA; OR, Odds ratio; CI, confidence interval; CVD, cardiovascular disease; OAI, Osteoarthritis Initiative.
*
Adjusted for age, sex, race, body mass index, history of knee injury/surgery, physical activity, and correlation between knees of each participant.