Table 2.
Longitudinal analyses on the relation of cardiovascular disease and diabetes with incident radiographic and symptomatic knee OA.
| Incident ROA at 60 months in MOST | Incident SxOA at 60 months in MOST | |||||
|---|---|---|---|---|---|---|
| N (knees) | Events | OR* (95% CI) | N (knees) | Events | OR* (95% CI) | |
| CVD | ||||||
| No | 2683 | 549 | 1.0 (reference) | 3551 | 546 | 1.0 (reference) |
| Yes | 280 | 53 | 0.80 (0.58–1.11) | 401 | 77 | 1.22 (0.89–1.67) |
| Diabetes | ||||||
| No | 2699 | 545 | 1.0 (reference) | 3634 | 559 | 1.0 (reference) |
| Yes | 208 | 54 | 0.88 (0.60–1.29) | 302 | 58 | 0.93 (0.65–1.31) |
| Incident ROA at 48 months in OAI | Incident SxOA at 48 months in OAI | |||||
| N (knees) | Events | OR* (95% CI) | N (knees) | Events | OR* (95% CI) | |
| CVD | ||||||
| No | 4180 | 637 | 1.0 (reference) | 5620 | 797 | 1.0 (reference) |
| Yes | 225 | 49 | 1.19 (0.81–1.74) | 322 | 64 | 1.19 (0.85–1.66) |
| Diabetes | ||||||
| No | 4181 | 641 | 1.0 (reference) | 5618 | 798 | 1.0 (reference) |
| Yes | 257 | 47 | 0.75 (0.50–1.14) | 376 | 67 | 0.82 (0.59–1.16) |
ROA, Radiographic OA; MOST, Multicenter Osteoarthritis Study; SxOA, symptomatic OA; OR, Odds ratio; CI, confidence interval; CVD, cardiovascular disease; OAI, Osteoarthritis Initiative.
*
Adjusted for age, sex, race, body mass index, history of knee injury/surgery, physical activity, and correlation between knees of each participant.