Table 1.

Effects of moderators

Schizophrenia						Major Depressive Disorder
Blood Compound	No. Analyses	Coefficient	95% Lower Limit	95% Upper Limit	P	Blood compound	No. Analyses	Coefficient	95% Lower Limit	95% Upper Limit	P
BDNF						BDNF
Age	8	0.04	-0.04	0.11	0.341	Age	7	0.03	-0.01	0.07	0.135
Sex (% males)	6	0.00	-0.01	0.02	0.660	Sex (% males)	7	0.01	−0.01	0.02	0.537
Treatment duration	9	0.00	−0.01	0.01	0.824	Treatment duration	7	0.08	−0.22	0.38	0.606
CRP	n/a					CRP	n/a
Glucose						Glucose	n/a
Age	17	0.01	−0.09	0.10	0.912
Treatment duration	17	−0.04	−0.12	0.05	0.401	IL-1β	n/a
BMI, before treatment	9	−0.53	−0.87	−0.18	0.003
BMI, change score	6	0.04	−0.53	0.61	0.886	IL-4	n/a
Illness duration	6	−0.22	−1.44	0.99	0.720
PANSS total, pre-treatment	8	−0.01	−0.03	0.02	0.693	IL-6	n/a
PANSS total, change score	6	0.01	−0.02	0.03	0.703
PANSS positive, pre-treatment	7	0.02	−0.07	0.10	0.740	TNFα
PANSS positive, change score	6	0.02	−0.05	0.09	0.623	Treatment duration	7	−0.64	−0.91	−0.37	< 0.001
PANSS negative, pre-treatment	7	−0.03	−0.14	0.09	0.651
PANSS negative, change score	6	0.02	−0.09	0.13	0.729
Sex (% males)	13	−0.01	−0.03	0.01	0.253
IL-1β	n/a
IL-4	n/a
IL-6
Age	7	−0.06	−0.15	0.04	0.243
Treatment duration	7	0.02	−0.02	0.05	0.360
PANSS total, pre-treatment	7	−0.03	−0.04	−0.01	0.002
PANSS total, change score	6	−0.01	−0.04	0.02	0.449
PANSS positive, pre-treatment	7	−0.10	−0.20	0.01	0.061
PANSS negative, pre-treatment	7	−0.13	−0.21	−0.06	0.001
PANSS negative, change score	6	−0.05	−0.14	0.04	0.291
Sex (% males)	7	0.04	−0.03	0.10	0.302
TNFα
Age	7	0.14	0.02	0.26	0.019
Sex (% males)	6	0.08	0.03	0.12	< 0.001
Treatment duration	7	0.00	−0.05	0.04	0.930

BMI, body-mass index; BDNF, brain-derived neurotrophic factor; CRP, C-reactive protein; IL, interleukin; n/a, not enough studies available for analysis; PANSS, Positive and Negative Syndrome Scale; TNFα, tumor necrosis factor alpha.

Meta-regression of continuous moderators was performed if at least six studies were available.