Skip to main content
. 2021 Feb 16;27(2):89–99. doi: 10.1089/ten.tec.2020.0296

Table 1.

Summary of Tissue-Engineered Innervated Skin Models

Skin cells Neurons Other cells Scaffold Objectives Source
Human from breast reduction Mouse DRG HUVEC Collagen I/III-chitosan sponge Model for studying peripheral nerve growth Gingras et al.57
Murine Murine motor neurons Murine Schwann cells Collagen I/III-chitosan sponge Neurite growth and myelination Gingras et al.50
Human from breast reduction Murine DRG HUVEC & murine Schwann cells Collagen I/II-chitosan sponge Neurite growth improvement with Schwann cells Blais et al.59
Human: Normal and Atopic Dermatitis Pig DRG None Collagen I hydrogel Neurite outgrowth in diabetic skin Roggenkamp et al.60
Human neonatal Mouse DRG HUVEC and HDMEC Collagen I/III + chitosan sponge Sensory neurons effect on wound closure. Blais et al.14
Human Mouse DRG None Collagen I/III-chitosan sponge Study effects of AGEs on skin pathophysiology and to study effects of anti-AGE molecules. Cadau et al.58
Human upper arm: healthy and diabetic Pig DRG None Collagen I hydrogel Study diabetes-associated cutaneous denervation. Reichert et al.61
Human neonatal fibroblasts and HaCaT Rat DRG None Cross-linked gelatin Model to study neuronal signal transduction Martorina et al.56
Human hiPSC-derived neurons or Mouse DRG (control) HDMEC (neonatal)- and hiPSC-derived Schwann cells Collagen I/III-chitosan sponge Fully human innervated skin model Muller et al.76
Human neonatal hiNSC Some: cell mix isolated from adipose tissue in hypodermis Dermis: collagen-silk
Hypodermis: silk sponge with collagen coating		 Full-thickness innervated skin model Vidal et al.78
Human neonatal hiNSC Some: cell mix isolated from adipose tissue in hypodermis Dermis: collagen-silk
Hypodermis: silk; collagen coating		 Model to study neuro-immuno-cutaneous interactions Vidal Yucha et al.79

AGE, advanced glycation end product; DRG, dorsal root ganglion; HDMEC, human dermal microvascular endothelial cell; hiNSC; human induced neuronal stem cell; hiPSC, human induced pluripotent stem cell; HUVEC, human umbilical vein endothelial cell.