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. 2021 Jan 22;34(1):3–17. doi: 10.1089/vim.2020.0022

FIG. 2.

FIG. 2.

Antigenic interactions of Bocaparvoviruses. (A) Capsid surface representation of HBoV1. The approximate locations of the 2-, 3-, and 5-fold axes are indicated along with the 2/5-fold wall and 3-fold protrusions. (B) Structural superimposition of VP monomers from different HBoVs. The VRs are labeled. (C) Depiction of the cryo-reconstructed density maps of the HBoV viral capsids complexed to the Fab portion of monoclonal antibodies. The viral strains shown here are HBoV1, 2, and 4, identified by the capsid wheel located to the left of the figure. Generic Fabs are docked onto the viral capsids at the appropriate locations identified by the cryo-reconstructed maps. These epitopes span the 3-fold and 5-fold axes of symmetry. The viral capsids in (A) and (B) are colored radially, such that regions closest to the center are colored purple, and those farthest away are colored red, with the Fabs colored gray, as indicated by the scale bar (bottom right in Fig. 1). These images were generated using PyMol (31). HBoV, human bocavirus. Color images are available online.