FIG. 4.

Antigenic Interaction of Erythroparvoviruses. (A) Structure of the VP monomer of Parvovirus B19. VRs are labeled. (B) Capsid surface representation of Parvovirus B19. The approximate locations of the 2-, 3-, and 5-fold axes are indicated along with the 2/5-fold wall and 3-fold protrusions. (C) Depiction of the cryo-reconstructed density map of the B19 viral capsid complexed to the Fab portion of a monoclonal antibody. The Fab was docked onto the viral capsid as identified by the cryo-reconstructed maps. The epitope spans the 5-fold axes of symmetry. The viral capsids in (A, B) are colored radially, such that regions closest to the center are colored purple, and those farthest away are colored red, with the Fabs colored gray, as indicated by the scale bar (bottom right in Fig. 1). These images were generated using PyMol (31). Color images are available online.