Fig. 3.
Comparative in vitro release profiles of in-house acyclovir cream formulations and marketed formulation (Cream 1). The IVRT method using immersion cells could establish the similarity between the release profiles of formulation F1 and Cream 1 having a similar composition. The method was also able to distinguish the differences in the release profiles of formulations F2 to F6, which differed in qualitative or quantitative compositions. The parameters used for IVRT: 200 mL of alkaline borate buffer (pH 9.2) maintained at 32°C, paddle speed of 150 rpm, immersion cell size 2 cm2, nitrocellulose membrane (0.45 μm pore size). Data expressed as mean ± SD (n = 6). IVRT, in vitro release testing.