Table 3.

Tylosin Phosphate Pharmacokinetic Model Parameters and Distributions

Parameter	Definition	Distribution	Unit	Realized range	References
δ	Degradation rate	LogNormal (−5.7, 0.7)	h−1	0.00039, 0.0034, 0.034	Ingerslev and Halling-Sorensen (2001), Scott Teeter and Meyerhoff (2003), Carlson and Mabury (2006), Storteboom et al. (2007), Dolliver et al. (2008), Cessna et al. (2011), Joy et al. (2014), Sura et al. (2014), Amarakoon et al. (2016), Ray et al. (2017)
λs	Rate of passage through the stomach	Uniform (0.05, 0.09)	h−1	0.05, 0.071, 0.09	Shaver et al. (1986), Zebeli et al. (2007)
λusi	Rate of passage through the upper small intestine	Uniform (0.2, 0.4)	h−1	0.2, 0.3, 0.4	Shaver et al. (1986), Martin et al. (1999)
λlsi	Rate of passage through the lower small intestine	Uniform (0.1, 0.2)	h−1	0.1, 0.15, 0.2	Shaver et al. (1986), Martin et al. (1999)
λi	Rate of passage through the large intestine	Uniform (0.1, 0.2)	h−1	0.1, 0.15, 0.2	Shaver et al. (1986)
μ	Fraction of TYL absorbed to digesta	Normal (0.7, 0.1) Truncate (0, 1)	—	0.38, 0.71, 0.97	Joint FAO/WHO Expert Committee on Food Additives (1991), Kowalski et al. (2002), Abu-Basha et al. (2012), Ji et al. (2014)

Realized range gives the minimum, median, and maximum rounded to two significant digits. Truncate gives the minimum and maximum allowed values.