Table 2 -. Brazilian initiatives on vaccine development for COVID-19.
Leading Institution | Platform | Type | Properties | Collaboration | Similar platform in use | |
FIOCRUZ-MG | INCT- Vacinasa | Replicating virus vector | Influenza vaccine vector | Bivalent vaccine. Takes advantage of the established use of influenza vaccine |
UFMG, USP (ICB, InCOR), Instituto Butantan, FMRP-USP | Seasonal influenza. |
Instituto Butantan | LDVb | Conjugated | OMV coupled with antigen | Great adjuvanticity conferred by OMV | - | OMVs are component of Meningitis B (Bexsero) |
RCDVc | Subunit vaccines, VLPs and chimeras | - | - | Several laboratories in the Institution | - | |
UFSC | CCB (MIP)d | Live attenuated vector | Recombinant BCG | Established vaccine against Tuberculosis. Worldwide used. Bivalent vaccine. |
UFMG, Instituto Butantan, UFRJ, Cambridge Univ., UKKarolinska Institutet (Sweden) | The vector is the current vaccine |
USP | FMUSP (InCOR)e | VLP | VLP containing spike protein | Mimics the viral structure | UFMG, USP (ICB), UNIFESP | HPV |
ICB (LDV)f | Nanoparticles | Self-assembly protein nanoparticles (SAPN) | Mimics the viral structure. Flexibility in the choice of antigens |
- | - | |
FCFg | Nanoparticles (spray) | Chitosan nanoparticles coupled with antigen | Nasal administration | - | - | |
Poli (PQI)h | Nanoparticles | Gold nanoparticles coupled with antigen | Custom size, shape and surface | USP (ICB) | - | |
UFV | DBGi | Replicating virus vector | Yellow fever vaccine vectored | Established vaccine. Bivalent vaccine |
UFV (DEM, DMB), FIOCRUZ-PE | The vector is the current vaccine |
a Instituto Nacional de Ciência e Tecnologia - Vacinas; b Laboratório de Desenvolvimento de Vacinas; c Rede Colaborativa de Desenvolvimento de Vacinas, d Microbiologia, Imunologia e Parasitologia do Centro de Ciências Biológicas (Universidade Federal de Santa Catarina); e Faculdade de Medicina da Universidade de São Paulo - Instituto do Coração; f Laboratório de Desenvolvimento de Vacinas do Instituto de Ciências Biomédicas; g Faculdade de Ciências Farmacêuticas; h Departamento de Engenharia Química da Escola Politécnica; i Departamento de Biologia Geral (Universidade Federal de Viçosa).