Skip to main content
. 2021 Apr 2;44(1 Suppl 1):e20200320. doi: 10.1590/1678-4685-GMB-2020-0320

Table 2 -. Brazilian initiatives on vaccine development for COVID-19.

Leading Institution Platform Type Properties Collaboration Similar platform in use
FIOCRUZ-MG INCT- Vacinasa Replicating virus vector Influenza vaccine vector Bivalent vaccine.
Takes advantage of the established use of influenza vaccine
UFMG, USP (ICB, InCOR), Instituto Butantan, FMRP-USP Seasonal influenza.
Instituto Butantan LDVb Conjugated OMV coupled with antigen Great adjuvanticity conferred by OMV - OMVs are component of Meningitis B (Bexsero)
RCDVc Subunit vaccines, VLPs and chimeras - - Several laboratories in the Institution -
UFSC CCB (MIP)d Live attenuated vector Recombinant BCG Established vaccine against Tuberculosis.
Worldwide used. Bivalent vaccine.
UFMG, Instituto Butantan, UFRJ, Cambridge Univ., UKKarolinska Institutet (Sweden) The vector is the current vaccine
USP FMUSP (InCOR)e VLP VLP containing spike protein Mimics the viral structure UFMG, USP (ICB), UNIFESP HPV
ICB (LDV)f Nanoparticles Self-assembly protein nanoparticles (SAPN) Mimics the viral structure.
Flexibility in the choice of antigens
- -
FCFg Nanoparticles (spray) Chitosan nanoparticles coupled with antigen Nasal administration - -
Poli (PQI)h Nanoparticles Gold nanoparticles coupled with antigen Custom size, shape and surface USP (ICB) -
UFV DBGi Replicating virus vector Yellow fever vaccine vectored Established vaccine.
Bivalent vaccine
UFV (DEM, DMB), FIOCRUZ-PE The vector is the current vaccine

a Instituto Nacional de Ciência e Tecnologia - Vacinas; b Laboratório de Desenvolvimento de Vacinas; c Rede Colaborativa de Desenvolvimento de Vacinas, d Microbiologia, Imunologia e Parasitologia do Centro de Ciências Biológicas (Universidade Federal de Santa Catarina); e Faculdade de Medicina da Universidade de São Paulo - Instituto do Coração; f Laboratório de Desenvolvimento de Vacinas do Instituto de Ciências Biomédicas; g Faculdade de Ciências Farmacêuticas; h Departamento de Engenharia Química da Escola Politécnica; i Departamento de Biologia Geral (Universidade Federal de Viçosa).