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. 2021 Mar 30;220(6):e202002084. doi: 10.1083/jcb.202002084

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© 2021 Kulkarni et al.

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Figure 3. — Synaptic activity does not alter AV motility in axons. (A) Kymographs of mCherry-LC3, tracked AVs (magenta denotes retrograde, cyan denotes anterograde, and dark blue denotes stationary segments), and GCaMP3 from the same axon after 60 min of treatment in 4-AP + Bic or CNQX + AP5. Horizontal bar, 5 µm. Vertical bar, 1 min. (B–D) Quantitation of AV mean speed in axons of rat hippocampal neurons treated with 4-AP + Bic or CNQX + AP5 for 60 min (B, mean ± SEM; C, histogram of axonal AV mean speed; D, cumulative frequency of axonal AV mean speed; n = 495–524 AVs from 21–23 neurons from three independent experiments, 13–14 DIV; unpaired t test).