Table 3. Comparison of mouse and rat Nav channel properties.
| Parameter | Mouse WTa | Mouse FGF14 KOa | Mouse Nav1.3 KOa | Mouse WTb | Ratc |
|---|---|---|---|---|---|
| G-V (V0.5) mV | −22.3 ± 0.3 | −17.2 ± 1.9 | −16.8 ± 2.7 | −21.9 | −27.4 ± 0.2 |
| SS inact (V0.5) mV; 25 ms | −35.5 ± 1.1 | −47.2 ± 2.1 | n.d. | n.d. | −39.2 ± 0.4 |
| SS inact (V0.5) mV; 1 s | −48.9 ± 1.0 | −58.0 ± 1.4 | −49.9 ± 3.3 | −47.9 mV | −57.7 ± 0.2 |
| Recovery voltage | −100 mV | −100 mV | −90 mV | −100 mV | |
| τrec1 (ms; A1) | 4.4 ± 0.5 (0.48) | 3.8 ± 0.3 (1.0) | n.d. | 4.8 (0.6) | 6.4 ± 0.6 (0.5) |
| τrec2 (ms; A2) | 335.3 ± 43.1 (0.54) | —— | n.d. | 156 (0.4) | 162.9 ± 1.8 (0.53) |
| Recovery voltage | −60 mV | −60 mV | −50 mV | −60 mV | |
| τrec1 (ms; A1) | 32.4 ± 2.7 (0.29) | 26.2 ± 1.1 (0.5) | n.d. | 23.7 (0.34) | 55.9 ± 1.1 (0.21) |
| τrec2 (ms; A2) | 1,136.4 ± 176 (0.49) | —— | n.d. | 229 (0.22) | 487.8 ± 7.6 (0.34) |
Data are fitted parameter ± 90% confidence limit. n.d., not determined.
a
This paper.
b
Vandael et al. (2015; perforated patch).