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. 2021 Mar 26;118(13):e2011269118. doi: 10.1073/pnas.2011269118

Fig. 1.

Fig. 1.

Activity of ERβ inhibits finasteride (Pro = Proscar) induced EGFR nuclear translocation in BPH. In BPH, EGFR was mainly expressed in the cell membrane (black arrow) (A). Finasteride treatment increased nuclear expression of EGFR (red arrows) (B). Combined treatment with finasteride and isoflavone decreased expression of EGFR in nuclei (black arrow) (C). (Scale bars, 50 μm). Statistical analyses of EGFR nuclear-positive cells in control, finasteride, or finasteride+isoflavone treated BPH (*P < 0.01) (D).