Fig. 1.
scRNAseq of spinal cords in SOD1G93A mouse model of ALS. (A) Schematic summarizing experimental design: whole spinal cords from 3.5-mo-old WT and SOD1G93A littermate male mice (n = 2 per group) treated with either a vehicle control or Nec-1s for 4 wk in drinking water were prepared using Drop-Seq and sequenced. (B) tSNE plot of cells isolated from all groups and identified based on differentially expressed genes generated using Seurat. n = 6 animals. (C) Proportion of each cell population across all samples. n = 6 animals. (D) tSNE plots of cells isolated plotted by group. n = 2 animals per group.