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. 2021 Mar 24;118(13):e2009620118. doi: 10.1073/pnas.2009620118

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Fig. 8. — High MCT1 expression in MYCN-amplified neuroblastoma. (A) The MCT1 expression in MYCN-amplified neuroblastoma tumors (n = 92) compared to MYCN wild-type neuroblastoma tumors (n = 401) from the SEQC database, MYCN-amplified neuroblastoma tumors (n = 93) compared to MYCN wild-type neuroblastoma tumors (n = 550) from the Kocak database and MYCN-amplified neuroblastoma tumors (n = 31) compared to MYCN wild-type neuroblastoma tumors (n = 220) from the Oberthuer database. (B) The MCT1 RNA expression from the CHLA20 GFP- expressing cells compared to the CHLA20 MYCN-expressing cells and the RPE.1 GFP-expressing cells compared to the RPE.1 MYCN-expressing cells as determined by qRT-PCR. (C) ChIP-seq of MYCN at the MCT1 promotor in MYCN-amplified NB cell lines, where read count peaks correspond to E-BOX sites in the MCT1 promoter. (D) The MCT1 and MYCN expression in the MCYN-expressing and non-MYCN–expressing SHEP21N cells. (E) Expression of MCT1 and MCT4 in MYCN-amplified and MCYN wild-type neuroblastoma. For MCT4, two points outside this range are not shown for visual purposes.