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Doxycycline induces a different structural arrangement in tau aggregates. Tau FTIR Amide I' curve fitting of (A) 100 μM tau (B) 100 μM tau in the presence of heparin (0.8 mg/ml). (C) 100 μM tau in the presence of heparin (0.8 mg/ml) and 100 μM doxycycline. Relative contribution of each component: (D) Random coil, (E) PPHII-helix, (F) β structure, (G) Cross-β. Error bars represent SD.
