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Ability of the Bayesian approach to estimate PKP for a drug following a two-compartment model given as described in Fig. 3. Correlations between true values and the Bayesian estimates were significant except for ka. Intercompartmental estimates are k10, k12, and k21, and the Vc and Vss are the Vd of the central compartment, and steady-state, respectively. Data construction and sampling is as described in Fig. 3. PKP, pharmacokinetic parameters; CL, clearance; Vd, volume of distribution.
